The work, which removed a gene mutation linked to a heart condition, is fueling debate over the controversial tool known as CRISPR. Two days after being injected with a gene-editing enzyme, these developing human embryos were free of a disease-causing mutation.
Two Words: “Unintended Consequences”
By Erin Blakemore
PUBLISHED by National Geographic, August 2, 2017
What if you could remove a potentially fatal gene mutation from your child’s DNA before the baby is even born? In an advance that’s as likely to raise eyebrows as it is to save lives, scientists just took a big step toward making that possible.
For the first time, researchers in the United States have used gene editing in human embryos. As they describe today in the journal Nature, the team used “genetic scissors” called CRISPR-Cas9 to target and remove a mutation associated with hypertrophic cardiomyopathy, a common inherited heart disease, in 42 embryos.
DNA Hacking Tool Enables Shortcut to Evolution
Scientists who want to explore the technique hail it as a biomedical advance that could one day give people the option not to pass down heritable diseases. The tool could also reduce the number of embryos that are discarded during fertility treatments because of worrisome genetic mutations.
“The scientists are out of control,” says George Annas, director of the Center for Health Law, Ethics & Human Rights at the Boston University School of Public Health, who thinks that scientists should not edit the genomes of human embryos for any reason. “They want to control nature, but they can’t control themselves.”
According to the Centers for Disease Control and Prevention, hypertrophic cardiomyopathy occurs in about one in 500 people. The condition causes the heart muscle to thicken and can lead to sudden cardiac arrest. It takes only one gene mutation to cause the condition, and you can get the disease even if only one of your parents has the mutated gene. If you inherit it, there’s a 50 percent chance you will pass it on to your children.
For their work, Shoukhrat Mitalipov, principal investigator at the Oregon Health and Science University’s Center for Embryonic Cell and Gene Therapy, and his colleagues targeted the genetic mutations that cause the majority of hypertrophic cardiomyopathy cases.
First, they created 58 human embryos from the sperm of a male donor with the mutation and the egg of a female without the mutation. Then, they used CRISPR to cut the mutation out of the gene. When things go right, the DNA repairs itself and the mutation disappears.
The technique isn’t always successful. In previous studies, some CRISPR-edited embryos developed mosaicism, a condition in which some cells have the unwanted mutations and others don’t. All in all, the team was able to repair the gene mutation in about 70 percent of the embryos, and the study showed no unwanted changes at other sites in the edited DNA.
The team allowed the fertilized cells to develop into blastocysts—the stage at which embryos are usually implanted into the mother during fertility treatments. They showed normal development, the team reports. Then, the embryos were destroyed.
Science in Motion
“Of course further research and ethical discussions are necessary before proceeding to clinical trials,” study coauthor Paula Amato, adjunct associate professor of obstetrics and gynecology at OHSU, said during a press briefing on August 1.
Earlier this year, the National Academy of Sciences and National Academy of Medicine asked an international committee of scientists and ethicists to weigh in on the benefits and risks of genome editing in humans. (Find out why scientists think gene editing is both terrifying and terrific.)
The panel recommended that in the case of the human germline—genes passed down from generation to generation—scientists refrain from editing genes for any purpose other than treating or preventing a disease or disability. (No more neurodiverse people will be allowed to be born? Where does this “elimination” of genetic diversity end?) The report also insisted on a more robust public debate before such experiments begin. (Oh sure, as if anyone in power will listen to the “peasants” at the bottom of the pyramid)
In the United States, there’s currently a ban on using taxpayer funds for any research that destroys human embryos. In this case they used institutional and private funds. If the team can’t move ahead as quickly as desired in the U.S., (blackmail?) they’ll consider pursuing their research in other countries.
Of course, poor and developing countries need the money and will sacrifice their embryos, and the “outcomes” for the population, good or bad, gladly…)
Debating the Future
It’s already possible to screen for genetic defects within embryos during in vitro fertilization using a process called preimplantation genetic diagnosis. The team thinks their CRISPR technique could eventually be applied to gene mutations associated with other diseases, like cystic fibrosis.
In their paper, the team writes that their method may one day “rescue mutant embryos, increase the number of embryos available for transfer and ultimately improve pregnancy rates (for the Elites who can $$$$ pay for it)
“That’s just absurd,” says Annas. “They admit right up front that if you want to avoid having a baby with [the mutation], you can just not implant the embryos that are affected.”
Mitalipov disagrees: “Discarding half the embryos is morally wrong,” he tells National Geographic. “We need to be more proactive.”
The embryos in this experiment were destroyed!
This is unbelievable: taking over the future evolution of our species, is “morally” right? Nature provides genetic variation which is necessary for organisms to adapt to a changing environment – we are not smart enough to interfere with this process.
Has anyone asked 7 billion humans if they think it’s a slam dunk “moral good” for a handful of scientists, who obviously are not the least concerned about morality or ethics, to just “go ahead” and terminate 3.5 billion years of evolution?
Either way, Annas says, it’s time to revisit the conversation about how to regulate CRISPR in the United States. “My guess is that the regulators will be horrified.” (Until $$$$ decides the issue)
But for Mitalipov, the debate is a chance to inform the world about the technique’s potential. And for a scientist who has also cloned monkey embryos and even cloned human embryos to make stem cells, he knows plenty about how to ignite public debate.
“We’ll push the boundaries,” he says.
Of course, “the rest of” Homo sapiens just don’t count; we have no choice but to submit to a future dictated by individuals who regard themselves as “GODS” The track record of “ethical nightmares” in human recent history (Eugenics, genocide, the Holocaust, chemical and biological warfare, and other mass murder of “defectives” – who are simply people of another race, religion, or ethnicity) has proven over and over that the power-insane “Male Psychopaths” at the top of the social pyramid are destroyers of Nature.